RESEARCH STUDIES
Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction
This treatment study is examining the effects of a behavioral intervention on smoking behavior in daily adult cigarette smokers who are interested in quitting smoking. Participants will either receive 4 weeks of MORE (Mindfulness Oriented Recovery Enhancement) or CBT (Cognitive Behavioral Therapy), and then make an attempt to quit smoking. The study will take place over the course of 8 weeks and will include group therapy sessions and two fMRI scans.
Mechanisms Underlying the Effects of Theta-burst Repetitive Transcranial Magnetic Stimulation on Nicotine Dependence
This study will examine the effects of continuous theta burst stimulation (cTBS) on cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours. During the study, participants will undergo a total of 4 fMRI scans and 3 cTBS treatment sessions.
PUBLICATIONS
2024
Smith, A., Azeem, M., Odhiambo, C.O., Wright, P.J., Diktas, H.E., Upton, S., Martin, C.K., Froeliger, B., Corbett, C.F., Valafar, H. (accepted). Toward Concurrent Identification of Human Activities with a Single Unifying Neural Network Classification: First Step. Sensors. PMID: Pending
Cofresi, R.U., Upton, S., Brown, A.A., Piasecki, T.M., Bartholow, B.D., Froeliger, B. (2024). Mesocorticolimbic system node reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: a pilot fMRI study. Addiction Neuroscience. PMID: 38938269.
Garland, E.L., Nakamura, Y., Brian, C.J., Hanley, A.W., Parisi, A., Froeliger, B., Marchand, W.R., & Donaldson, G.W. (2024). Mindfulness-Oriented Recovery Enhancement for veterans and military personnel on long-term opioid therapy for chronic pain: A randomized clinical trial. American Journal of Psychiatry. PMID: 38196335
Jones, S., Wolf, B.J., Wallace, K., Froeliger, B., Carpenter, M.J., Alberg, A.J. (accepted). Single nucleotide polymorphisms within DRD2, COMT, and DBH and smoking cessation: A systematic review considering genetic differences by ancestry and biological sex. Current Addiction Reports.
Massey, Z.B., Hammond, D., Froeliger, B. (2024). A Narrative Systematic Review of Cannabis Health Warning Research. Preventative Medicine Reports. PMID: 38222305
Rolbiecki, AJ, Froeliger, B., Smith, J., Ying, J., Canfield, SM., Posley, K., Polniak, M., & Dotson, D. (2024). Virtual Reality and Neurofeedback as a supportive approach to managing cancer symptoms for patients receiving treatment: A brief report of a feasibility trial. Palliative and Supportive Care. PMID: 38454804
Rolbiecki, A., Froeliger, B., Ying, J. (2024). Virtual Reality and Neurofeedback: An Innovative Approach for Managing Cancer Symptoms (RP102). Journal of Pain and Symptom Management, Volume 67, Issue 5, e803 - e804
2023
Brown, A., Cofresi, R., Froeliger, B. (2023). Associations between the Wisconsin Inventory of Smoking Dependence Motives (WISDM-68) and Regional Brain Volumes in Adult Smokers. Nicotine and Tobacco Research. PMID: 37338201
Brown, A., Upton, S., Craig, S., Froeliger, B. (2023). Associations Between Right Inferior Frontal Gyrus Morphometry and Cognitive Control in Individuals with Nicotine Dependence. Drug and Alcohol Dependence. PMID: 36640686
Garland, E.L., Fix, S., Hudak, J.M., Bernat, E., Nakamura, Y. Hanley, A.W., Donaldson, G.W., Marchand, W., & Froeliger, B. (2023). Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards. Psychological Medicine. PMID: 37310337
Jones, S., Alberg, A.J., Wallace, K., Froeliger, B., Carpenter, M.J., Wolf, B.J. (2023). CHRNA5-A3-B4 and DRD2 genes and smoking cessation throughout adulthood: A longitudinal study of women. Nicotine and Tobacco Research. Feb 16;ntad026. doi: 10.1093/ntr/ntad026. PMID: 36794842.
Jones, S., Alberg, A.J., Wallace, K., Froeliger, B., Carpenter, M.J., Wolf, B.J. (2023). Genetic associations with cigarette smoking relapse and proportion of follow-up in smoking relapse throughout adulthood in pre- and post-menopausal women. Cancer Prevention Research. Apr 13;OF1-OF12. PMID: 37070666.
Palmer, A.M., Carpenter, M.J., Baker, N.L., Froeliger, B., Foster, M.G., Garland, E.L., Saladin, M.E., Toll, B.A (2023). Development of Two Novel Treatments to Promote Smoking Cessation: Savor and Retrieval Extinction Training Pilot Clinical Trial Findings. Experimental and Clinical Psychopharmacology. Mar 13. doi: 10.1037/pha0000644. PMID: 36913266.
Parisi, A., Hudak J., Froeliger, B., & Garland, E.L. (2023). Mindfulness-Oriented Recovery Enhancement reduces posttraumatic stress by enhancing reappraisal among chronic pain patients with co-occurring opioid misuse. Nature Mental Health. PMCID: Pending
Rolbiecki, A.J., Govindarajan, A., Froeliger B. (2023). Immersive Virtual Reality and Neurofeedback for the Management of Cancer Symptoms during Treatment. Support Care Cancer. 2023 Jul 26;31(8):493. doi: 10.1007/s00520-023-07957-3. PMID: 37493785
Sahlem GL, Dowdle LT, Baker NL, Sherman BJ, Gray KM, McRae-Clark AL, Froeliger B, Squeglia LM. Exploring the Utility of a Functional Magnetic Resonance Imaging (fMRI) Cannabis Cue-Reactivity Paradigm in Treatment Seeking Adults with Cannabis Use Disorder. medRxiv [Preprint]. 2023 Nov 16:2023.11.14.23298485. doi: 10.1101/2023.11.14.23298485. PMID: 38014250; PMCID: PMC10680897.
Sherman, B.J., Brasher, Z.B., Baker, N.L., McRae-Clark, A.L., Froeliger, B. (2023). Restructuring reward: A pilot study to enhance natural reward response in adults with cannabis use disorder. Drug and Alcohol Dependence. PMID: 37329729
Upton, S., Brown, A., Garland, E.L., Ithman, M., Froeliger, B. (2023). Continuous Theta-Burst Stimulation to Right Inferior Frontal Gyrus Attenuates Smoking Behaviors and Strengthens Fronto-Striatal-Limbic Resting-State Functional Connectivity. Frontiers in Psychiatry. 2023 Jun 28;14:1166912. doi: 10.3389/fpsyt.2023.1166912. eCollection 2023. PMID: 37457779
Upton, S., Brown, A., Ithman, M., Newman-Norlund, R., Sahlem, G., Prisciandaro, J., McClure, E.A., Froeliger, B. (2023). Effects of Hyperdirect Pathway Theta-Burst Transcranial Magnetic Stimulation on Inhibitory Control, Craving, and Smoking in Adults with Nicotine Dependence: A Double-Blind Randomized Crossover Trial. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. PMID: 37567363
Verdejo-Garcia, A. et al., (2023). Cognitive training and remediation interventions for substance use disorders: A Delphi consensus study. Addiction. May;118(5):935-951. doi: 10.1111/add.16109. PMID: 36508168
2022 and older
Garland, E.L., Hanley, A.W., Hudak, J., Nakamura, Y., Froeliger, B. (2022). Mindfulness-Induced Endogenous Theta Stimulation Occasions Self-Transcendence and Inhibits Addictive Behavior. Science Advances. PMCID: PMC9555770
Garland, E.L., Hanley, A., Nakamura, Y., Baker, A.K., Reese, S.E., Riquino, M.R., Froeliger, B., Donaldson, G.W., Howard, M.O. (2022). Mindfulness-Oriented Recovery Enhancement for Opioid Misuse and Chronic Pain in Primary Care: A Randomized Controlled Trial. JAMA Internal Medicine. PMID: 35226053. PMCID: PMC8886485
Hudak, J., Bernat, E.M., Fix, S.T., Prince, K.C., Froeliger, B., & Garland, E.L. (2022). Neurophysiological deficits during reappraisal of negative emotional stimuli in opioid misuse. Biological Psychiatry. PMID: 35393080
Jones, S., Wolf, B.J., Froeliger, B., Wallace, K., Carpenter, M.J., Alberg, A.J. (2022). A systematic review of genetic variation within nicotinic acetylcholine receptor genes and cigarette smoking cessation. Drug and Alcohol Dependence. PMID: 35981468
Jones, S., Wolf, B.J., Froeliger, B., Wallace, K., Carpenter, M.J., Alberg, A.J. (2022). Nicotine metabolism predicted by CYP2A6 genotypes in relation to smoking cessation: A systematic review. Nicotine & Tobacco Research. PMID: 34478556.
Miller, M. B., Boness, C. L., DiBello, A. M., & Froeliger, B. (2022). Insomnia as a moderator of alcohol use and blackout: Potential role in acute physiological consequences. Addictive Behaviors. PMID: 35696822
Nall, R.W., Belote, L.N., Meyerink, M.E., Penaloza, T., Doolittle, J., Froeliger, B., Kalivas, P.W., Garcia-Keller, C. (2022). Assessing Combined Effects of Varenicline and N-acetylcysteine on Reducing Nicotine Seeking in Rats. Addition Biology. PMID: 35229943.
Parisi, A., Landicho, H.L., Hudak, J., Leknes, S., Froeliger, B., Garland, E.L. (2022). Emotional distress and pain catastrophizing predict cue-elicited opioid craving among chronic pain patients on long-term opioid therapy. Drug Alcohol Dependence. PMID: 35278786
Bell, S., Froeliger, B. (2021). Associations Between Smoking Abstinence, Inhibitory Control, and Lapse Vulnerability: An fMRI Study. Frontiers in Psychiatry – Addictive Disorders. PMID: 33868037.
Carpenter MJ, Gray KM, Wahlquist AE, Cropsey K, Saladin ME, Froeliger B, Smith TT, Toll BA, Dahne J. (2021). A Pilot Randomized Clinical Trial of Remote Varenicline Sampling to Promote Treatment Engagement and Smoking Cessation. Nicotine Tob Res. PMID: 33249458
Cole, C., Powers, S., Tomko, R., Froeliger, B., Valafar, H. (2021). Quantitation of Smoking Characteristics using Smartwatch Technology: Pilot Feasibility Study of New Technology. JMIR Formative Research. PMID: 33544083
Garland, E.L., Fix, S., Hudak, J.M., Bernat, E., Nakamura, Y. Hanley, A.W., Donaldson, G.W., Marchand, W., & Froeliger, B. (2021). Mindfulness-Oriented Recovery Enhancement remediates anhedonia in chronic opioid use by enhancing neurophysiological responses during savoring of natural rewards. Psychological Medicine. PMID: Pending
Hudak, J., Prince, K., Marchand, W., Nakamura, Y., Hanley, A., Bryan, C., Froeliger, B., Garland, E.L. (2021). The Temporal Dynamics of Emotion Dysregulation in Prescription Opioid Misuse. Progress in Neuropsychopharmacology & Biological Psychiatry. PMID: 32589895.
Stephanie K Jones, MS, Bethany J Wolf, PhD, Brett Froeliger, PhD, Kristin Wallace, PhD, Matthew J Carpenter, PhD, Anthony J Alberg, PhD (2021). Nicotine metabolism predicted by CYP2A6 genotypes in relation to smoking cessation: A systematic review, Nicotine & Tobacco Research, 2021; ntab175, https://doi.org/10.1093/ntr/ntab175
Halbert CH, Jefferson MS, Danielson C, Froeliger, B, Giordanoa A, Thaxton J. (2020). An observational study and randomized trial of stress reactivity in cancer disparities. Health Psychology. Sep;39(9):745-757. doi: 10.1037/hea0000882. PMID: 32833476
McConnell, P. A., E. L. Garland, J. K. Zubieta, R. Newman-Norlund, S. Powers and Froeliger, B. (2020). "Impaired frontostriatal functional connectivity among chronic opioid using pain patients is associated with dysregulated affect." Addict Biol. Mar;25(2):e12743. doi: 10.1111/adb.12743. Epub 2019 Apr 4. PMID: 30945801
Newman-Norlund, R., Gibson, M., McConnell, P., Froeliger, B. (2020). Dissociable effects of theta-burst repeated transcranial magnetic stimulation to the inferior frontal gyrus on inhibitory control in nicotine addiction. Frontiers in Psychiatry. Apr 15;11:260. PMID: 32351412
Garland, E.L., Atchley, R., Howard, M., Zubieta, J-K., Froeliger, B. (2019). Mindfulness-Oriented Recovery Enhancement Restructures Reward Processing Among Chronic Opioid Users: Neurophysiological and Affective Evidence. Science Advances 5(10). PMID 31663023
Garland, E. L., M. A. Bryan, S. E. Priddy, M. R. Riquino, Froeliger, B., and M. O. Howard (2019). "Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study." Ann Behav Med 53(10): 865-876. PMID: 30668631
Garland, E. L., A. W. Hanley, M. R. Riquino, S. E. Reese, A. K. Baker, K. Salas, B. P. Yack, C. E. Bedford, M. A. Bryan, R. Atchley, Y. Nakamura, Froeliger, B., and M. O. Howard (2019). "Mindfulness-oriented recovery enhancement reduces opioid misuse risk via analgesic and positive psychological mechanisms: A randomized controlled trial." J Consult Clin Psychol 87(10): 927-940. PMID: 31556669
Mathew, A. R., B. W. Heckman, B. Froeliger, M. E. Saladin, R. A. Brown, B. Hitsman and M. J. Carpenter (2019). "Multi-method assessment of distress tolerance and smoking-related factors among adult daily smokers." Exp Clin Psychopharmacol 27(2): 136-145. PMID: 30589279
Tomko, R. L., Froeliger, B., McClure, E. A., Saladin, M.E., and Gray, K.M. (2019). Gender Differences in Smoking Latency Following Exposure to Stressful Images Administered in Naturalistic Settings. Journal of Womens Health. 28 (11): 1593-1593.
Tomko, R. L., E. A. McClure, P. A. Cato, J. B. Wang, M. J. Carpenter, J. L. Karelitz, Froeliger, B., M. E. Saladin and K. M. Gray (2019). "An electronic, smart lighter to measure cigarette smoking: A pilot study to assess feasibility and initial validity." Addict Behav 98: 106052. PMID: 31415971
Garland, E.L., Atchley, R., Howard, M., Zubieta, J-K., Froeliger, B. (accepted). Mindfulness-Oriented Recovery Enhancement Reduces Opioid Misuse Risk Via Analgesic and Positive Psychological Mechanisms: A Randomized Controlled Trial. Journal of Consulting and Clinical Psychology
Garland, E.L., Bryan, M.A., Priddy, S.E., Riquino, M.R., Froeliger, B., Howard, M.O. (in press). Effects of Mindfulness-Oriented Recovery Enhancement Versus Social Support on Negative Affective Interference During Inhibitory Control Among Opioid-Treated Chronic Pain Patients: A Pilot Mechanistic Study. Annals of Behavioral Medicine. Jan 22. PMID: 30668631.
Fridriksson, J.F., Rorden, C., Newman-Norlund, R., Froeliger,B., Thrasher, J. (2018). Smokers' Neurological Responses to Novel and Repeated Health Warning Labels (HWLs) from Cigarette Packages. Frontiers in Psychology.
Badran, B.W., Austelle, C.W., Smith, N.R., Glusman, C.E., Froeliger, B., Garland, E.L., Borckardt, J.J., George, M.S., Short, B. (2017). A double-blind study exploring the use of transcranial direct current stimulation (tic’s) to potentially enhance mindfulness meditation (E-meditation). Brain Stimulation. Jan-Feb; 10 (1): 152-154. PMID: 27839723.
Carpenter MJ, Heckman BW, Wahlquist AE, Wagener TL, Goniewicz ML, Gray KM, Froeliger B, Cummings KM. A naturalistic, randomized pilot trial of e-cigarettes: Uptake, exposure, and behavioral effects. Cancer Epidemiology, Biomarkers & Prevention. 2017;26:1795-803. PMCID: 5713898.
Froeliger, B., Mathew, A.R., McConnell, P.A., Eichberg, C., Saladin, M.E., Carpenter, M.J., Garland, E.L. (in press). Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. Evidence-Based Complementary and Alternative Medicine: eCAM 2017.
Froeliger, B., McConnell, P.A., Sweitzer, M.A., Bell, S., Kozink, R.V., Eichberg, C., Gray, K.M., McClernon, F.J. (2017). Association Between Baseline Corticothalamic-Mediated Inhibitory Control and Smoking Relapse Vulnerability. JAMA Psychiatry. Mar 1. doi:10.1001/jamapsychiatry.2017.0017
Garland, E.L., Froeliger, B., Howard, M.O. (2017). Deficits in Autonomic Indices of Emotion Regulation and Reward Processing Associated with Prescription Opioid Use and Misuse. Psychopharmacology. Feb; 234 (4): 621-629, PMID: 27933366.
Garland, E.L., Howard, M.O., Priddy, S., McConnell, P.A., Riquino, M.R., Froeliger, B. (in press). Mindfulness Training Applied to Addiction Therapy: Insights into the Neural Mechanisms of Positive Behavioral Change. Neuroscience and Neuroeconomics.
Garland, E.L., Howard, M.O.. Zubieta, J.K., Froeliger, B. (2017). Restructuring Hedonic Dysregulation in Chronic Pain and Prescription Opioid Misuse: Effects of Mindfulness-Oriented Recovery Enhancement on Responsiveness to Drug Cues and Natural Rewards. Psychotherapy and Psychosomatics. Feb 10;86(2):111-112. PMID: 28183077
Germeroth, L.J., Carpenter, M.J., Baker, N.L., Froeliger, B., LaRowe, S.D., Saladin, M.E. (2017). A Brief Memory Updating Intervention Significantly Attenuates Smoking Behavior. JAMA Psychiatry. Feb 1.PMID: 28146243.
Meier, E., Wahlquist, A.E., Heckman, B.W., Cummings, K.M., Froeliger, B., Carpenter, M.J. (2017). A Pilot Randomized Crossover Trial of E-cigarette Sampling Among Smokers. Nicotine and Tobacco Research, Feb; 19 (2): 176-182. PMID: 27613880.
McClernon, F.J., Froeliger, B., Rose, J.E., Kozink, R.V., Addicott, M.A., Sweitzer, M.M., Westman, E.C., Van Wert, D.M. (2016). The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addiction Biology. Jul; 21 (4): 954-61. PMID: 25904425.
Osmana, A., Cayir, E., Perez, H., Thrasher, J.F., Froeliger, B. (2016). Depressive symptoms and responses to cigarette pack warning labels among Mexican smokers. Health Psychology; Feb 11. PMID: 26867043.
Addicott, M.A., Sweitzer, M.M., Froeliger, B., McClernon, F.J. (2015). Increased functional connectivity in an insula-based network is associated with improved smoking cessation outcomes. Neuropsychopharmacology; Oct; 40 (11): 2648-56. PMID: 25895453.
Cortese, B.M., McConnell, P.A., Froeliger, B., Leslie, K., Uhde, T.W. (2015). Burning odor-elicited anxiety in OEF/OIF combat veterans: inverse relationship to gray matter volume in olfactory cortex. Journal of Psychiatric Research. PMID: 26424424.
Froeliger, B., McConnell, P.A., Stankeviciute, N., McClure, E.A., Kalivas, P.W., Gray, K.M. (2015). The effects of N-Acetylcysteine on frontostriatal resting-state functional connectivity, withdrawal symptoms and smoking abstinence: A double-blind, placebo-controlled fMRI pilot study. Drug and Alcohol Dependence. doi:10.1016/j.drugalcdep.2015.09.021. PMID: 26454838.
Garland, E.L., Froeliger, B., Howard, M.O. (2015). Allostatic Dysregulation of Natural Reward Processing in Prescription Opioid Misuse: Autonomic and Attentional Evidence. Biological Psychology. Feb;105:124-9. PMID: 25603284.
Garland, E.L., Froeliger, B., Howard, M.O. (2015). Neurophysiological Evidence for Remediation of Reward Processing Deficits in Chronic Pain and Opioid Misuse Following Treatment with Mindfulness-Oriented Recovery Enhancement: Exploratory ERP Findings from a Pilot RCT. Journal of Behavioral Medicine. Jun;82(3):448-59. doi: 10.1007/s10865-014-9607-0. Epub 2014 Nov 11. PMID: 25385024.
Garland, E, Hanley, A., Farb, N., Froeliger, B. (2015). State Mindfulness During Meditation Predicts Enhanced Cognitive Reappraisal. Mindfulness. Apr 1;6(2):234-242. PMID: 26085851.
Heckman, B., Carpenter, M., Correa, J., Wray, J., Saladin, M., Froeliger, B., Drobes, D., Brandon, T. (2015). Acute Negative Affect Manipulations Increase Smoking Behavior: A Meta-Analysis. Addiction. May;110(5):751-60. PMID: 25641624.
Mathew, A.R., Burris, J.L., Froeliger, B., LaRowe, S.D., Saladin, M.E., Carpenter, M.J. (2015). Impulsivity and Cigarette Craving among Adolescent Daily and Occasional Smokers. Addictive Behaviors. Jun;45:134-8. PMID: 25665916.
McClure, E.A., Baker, N.L., Gipson, C.D., Carpenter, M.J., Roper, A., Froeliger, B.E, Kalivas, P.W., Gray, K.M (2015). An open-label pilot trial of N-acetylcysteine and varenicline in adult cigarette smokers. The American Journal of Drug and Alcohol Abuse. Jan;41(1):52-6. PMID: 25062287.
McConnell, P.A., Froeliger, B. (2015). Mindfulness, Mechanisms and Meaning: Perspectives from the Cognitive Neuroscience of Addiction. Psychological Inquiry. PMID: 26924915.
Addicott, M.A., Pearson, J.M., Froeliger, B., Platt, M.L., McClernon, F.J. (2014). Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. Psychiatry Research: Neuroimaging. Dec 30;224(3):254-61. PMID: 25453166
Addicott, M.A., Froeliger, B., Kozink, R.V., Van Wert, D.M., Westman, E.C., Rose, J.E., McClernon, F.J. (2014). Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology. Nov;39(12):2750-9. PMID: 24820539.
Garland, E.L., Froeliger, B., Howard, M.O. (2014). Effects of Mindfulness-Oriented Recovery Enhancement on Reward Responsiveness and Opioid Cue-Reactivity. Psychopharmacology. Aug;231(16):3229-38. PMID: 24595503.
Garland, E.L., Froeliger, B., Howard, M.O. (2014). Mindfulness training targets neurocognitive mechanisms of addiction at the attention-appraisal-emotion interface. Frontiers in Psychiatry. Jan 10;4:173. PMID: 24454293.
Garland, E.L., Manusov, E., Froeliger, B., Kelly, A., Williams, J., Howard, M. (2014). Mindfulness-Oriented Recovery Enhancement for Chronic Pain and Prescription Opioid Misuse: Results from an Early Stage Randomized Controlled Trial. Journal of Consulting and Clinical Psychology. Jun;82(3):448-59. PMID: 24491075.
McConnell, P, Froeliger, B., Garland, E.L., Ives, J,C., Sforzo, G.A. (2014). Auditory driving of the autonomic nervous system: Listening to theta-frequency binaural beats post-exercise increases parasympathetic activation and sympathetic withdrawal. Frontiers in Psychology.Nov 14;5:1248. PMID: 25452734.
Newman-Norlund, R., Thrasher, J., Fridrikson, J., Brixius, W., Froeliger, B., Hammond, D., Cummings, M. (2014). Neural biomarkers for assessing the effects of different types of imagery in pictorial health warning labels on cigarette packaging. BMJ Open. Dec 31;4(12). PMID: 25552613.
Szabo, S.T., Fowler, J.C., Froeliger, B., Lee, T.H. (2014). Time-dependent changes in nicotine behavioral responsivity during early withdrawal from chronic cocaine administration and attenuation of cocaine sensitization by mecamylamine. Behavioural Brain Research. Apr 1;262:42-6. PMID: 24412684.
Diggs, G., Froeliger, B., Gilbert, D.G. (2013). Smoker-nonsmoker differences in neural response to appetitive and threatening cues: An fMRI investigation. Psychiatry Research: Neuroimaging. Jan 30;211(1):85-7. PMID: 23146252.
Froeliger, B., Modlin, L.A., Kozink, R.V., Wang, L., Garland, E.L., Addicott, M.A., McClernon, F.J. (2013). Frontoparietal Attentional Network Activation Differs Between Smokers and Nonsmokers During Affective Cognition. Psychiatry Research: Neuroimaging. Jan 30;211(1):57-63. PMID: 23154092.
Garland, E.L., Froeliger, B., Passik, S., Howard, M.O. (2013). Attentional Bias For Prescription Opioid Cues Among Opioid-Dependent Chronic Pain Patients. Journal of Behavioral Medicine. Dec;36(6):611-20. PMID: 22968666.
Garland, E. L., Froeliger, B., Zeidan, F., Suveg, K., & Howard, M. O. (2013). The downward spiral of chronic pain, prescription opioid misuse, and addiction: Cognitive, affective, and neuropsychopharmacologic pathways. Neuroscience & Biobehavioral Reviews. Dec;37(10 Pt 2):2597-607. PMID: 23988582.
Felder, J.N., Smoski, M.J., Kozink, R.V., Froeliger, B., McClernon, F.J., Bizzell, L., Petty, C., Dichter, G.S. (2012). Functional Neural Correlates of Moderate Depressive Symptoms: A Pilot Study. BMC Psychiatry, 12, 1. PMID: 22998631
Froeliger, B. Garland, E., & McClernon, F.J. (2012). Yoga meditation practitioners exhibit greater gray matter volume and fewer reported cognitive failures: Results of a preliminary voxel-based morphometric analysis. Evidence-Based Complementary and Alternative Medicine: eCAM 2012: 821307. PMID: 23304217.
Froeliger, B., Beckham, J.C., Feldman, M., Kozink, R.V., McClernon, F.J. (2012). Effects of nicotine administration on emotional reactivity in PTSD and non-PTSD smokers: Results of a preliminary fMRI study. Advances in Pharmacological Sciences, vol 2012, Article ID 265724, 6 pages. PMID: 22719754.
Froeliger, B., Garland, E.L., Modlin, L.A., McClernon, F.J. (2012). Neurocognitive correlates of the effects of yoga meditation practice on emotion and cognition: a pilot study. Frontiers in Integrative Neuroscience, 6. PMID: 22855674
Froeliger, B., Garland, E.L., Kozink, R.V. et al., (2012) Meditation-State Functional Connectivity (msFC): Strengthening of the Dorsal Attention Network and Beyond, Evidence-Based Complementary and Alternative Medicine. vol. 2012, Article ID 680407, 9 pages, 2012. PMID: 22536289.
Froeliger, B., Modlin, L.A., Kozink, R.V., Wang, L., McClernon, F.J. (2012). Smoking Abstinence and Depressive Symptoms Modulates the Executive Control System During Emotional Information Processing. Addiction Biology,17, 668-679. PMID: 22081878.
Froeliger, B., Modlin, L.A., Wang, L., Kozink, R.V., McClernon, F.J. (2012). Nicotine Withdrawal Modulates Frontal Brain Function During an Affective Stroop Task. Psychopharmacology, 220, 707-18. PMID: 21989805.
Rose, J.E., McClernon, F.J., Froeliger, B., Behm, F.M., Preud'homme, X., Krystal, A. (2011). Repetitive transcranial magnetic stimulation (rTMS) of the superior frontal gyrus modulates craving for cigarettes. Biological Psychiatry, 70, 794-799. PMID: 21762878.
Froeliger, B., Kozink, R.V., Rose, J.E., Behm, F.M., Salley, A.N., and McClernon, F.J. (2010). Hippocampal and striatal grey matter volume are associated with a smoking cessation treatment outcome: Results of an exploratory voxel-based morphometric analysis. Psychopharmacology, 210, 577-583. PMID: 20424827.
Kozink, R. V., Lutz, A. M., Rose, J. E., Froeliger, B., & McClernon, F. J. (2010). Smoking withdrawal shifts the spatiotemporal dynamics of neurocognition. Addiction Biology, 15, 480-490. PMID: 21040240.
Carlson, J.M., Gilbert, D.G., Rise, H., Huber, J., Rabinovich, N.E., Froeliger, B., & Sugai, C. (2009). Serotonin Transporter Genotype and Trait Depression Influence the Benefit of Nicotine on Spatial Working Memory. Experimental and Clinical Psychopharmacology, 17, 173-180. PMID: 19586232.
Froeliger, B., Gilbert, D.G., & McClernon, F.J. (2009). Effects of Nicotine on Novelty Detection and Memory Recognition Performance: Double-Blind, Placebo-Controlled Studies of Smokers and Nonsmokers. Psychopharmacology, 205, 625-633. PMID: 19488741.
Gilbert, D.G., Carlson, J.M., Rise, H., Huber, J., Rabinovich, N.E., Sugai, C., & Froeliger, B.E. (2008). Effects of nicotine and depressive traits on affective priming of lateralized emotional word identification. Experimental and Clinical Psychopharmacology, 16, 293-300. PMID: 18729683.
Gilbert, D. G., Sugai, C., Zuo, Y., Rabinovich, N. E., McClernon, F. J., & Froeliger, B. E. (2007). Brain indices of nicotine’s effects on attentional bias to smoking and emotional pictures and to task-relevant targets. Nicotine and Tobacco Research, 9, 351-363. PMID: 17365767.
THE TEAM
BRETT FROELIGER, Ph.D.
DIRECTOR, THE HEALTH NEUROSCIENCE CENTER
Professor in the Department of Psychiatry and Psychological Sciences
University of Missouri
froeligerb@health.missouri.edu
573-882-4785
DIRECTOR
GRADUATE STUDENTS
ROBIN ARNOLD
GRADUATE STUDENT
Department of Psychological Sciences
University of Missouri
443-717-3048
PIAS MALAKER, M.S.
MD - PHD STUDENT
School of Medicine
University of Missouri
SPENCER UPTON, M.S.
GRADUATE STUDENT
Department of Psychological Sciences
University of Missouri
573-882-7568
RESEARCH STAFF
NICHOLAS HENIGMAN, B.A.
RESEARCH SPECIALIST
Department of Psychological Sciences
University of Missouri
573-340-5643
MATTHEW MARTIN, B.S.
MRI TECH, LAB AND BUILDING MANAGER
Department of Psychological Sciences
University of Missouri
573-882-2977
DEVON TERRY, B.A.
PROGRAM COORDINATOR
Departments of Psychiatry & Psychological Sciences
University of Missouri
573-882-7568
TYLEE WILLIAMS-SCHNAKE, B.A.
RESEARCH SPECIALIST
Department of Psychological Sciences
University of Missouri
573-882-8913
ALUMNI
ALEX BROWN, B.S.
DATA ANALYST
STEPHEN CRAIG, B.S.
MRI TECH AND RESEARCH COORDINATOR
ANDREW TAIT, B.S.
RESEARCH SPECIALIST
MADHURA ATHREYA, M.S.
LAB MANAGER
CONTACT US
PHONE AND TEXT
For Details, call or text: (573) 340-8636
Text "SMOKE" to 21000 to see if you are eligible
healthneurosciencecenter@gmail.com
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